{"id":771,"date":"2024-04-02T20:22:38","date_gmt":"2024-04-03T03:22:38","guid":{"rendered":"https:\/\/cloudbreakpharma.com\/?page_id=771"},"modified":"2026-06-05T11:53:41","modified_gmt":"2026-06-05T18:53:41","slug":"cbt-001-pterygium-eye-drop","status":"publish","type":"page","link":"https:\/\/cloudbreakpharma.com\/zh\/pipeline\/cbt-001-pterygium-eye-drop\/","title":{"rendered":"CBT-001"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"771\" class=\"elementor elementor-771\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f0b21f1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f0b21f1\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b30f889\" data-id=\"b30f889\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fc87f17 elementor-widget elementor-widget-heading\" data-id=\"fc87f17\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">CBT-001<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-89d9907 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"89d9907\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eac25f5\" data-id=\"eac25f5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ef23022 elementor-widget elementor-widget-heading\" data-id=\"ef23022\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u4e00\u79cd\u9488\u5bf9\u7ffc\u72b6\u80ec\u8089\u60a3\u8005\u7684\u6f5c\u5728\u9996\u521b\u7597\u6cd5<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-090b662 elementor-widget elementor-widget-text-editor\" data-id=\"090b662\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3 class=\"p1\" style=\"text-align: center;\"><span class=\"s1\" style=\"color: #ffffff;\">CBT-001 \u76ee\u524d\u6b63\u5904\u4e8e3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff08NCT05456425\uff09\uff0c\u4f5c\u4e3a\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u7ffc\u72b6\u80ec\u8089\u7684\u6539\u53d8\u75be\u75c5\u8fdb\u7a0b\uff08disease-modifying\uff09\u6ef4\u773c\u6db2\u7597\u6cd5\u3002<\/span><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-13bba45 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"13bba45\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f530c01\" data-id=\"f530c01\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6f05c25 elementor-widget elementor-widget-heading\" data-id=\"6f05c25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u7a81\u7834\u6027\u521b\u65b0<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d4730f elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"9d4730f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\"><span class=\"s1\">\u6211\u4eec\u7684\u6838\u5fc3\u4ea7\u54c1 CBT-001 \u662f\u4e00\u79cd\u6f5c\u5728\u7684\u540c\u7c7b\u9996\u521b\uff08first-in-class\uff09\u836f\u7269\u7597\u6cd5\uff0c\u91c7\u7528\u9488\u5bf9\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08\u201cPDGFRs\u201d\uff09\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08\u201cFGFRs\u201d\uff09\u548c\u8840\u7ba1\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08\u201cVEGFRs\u201d\uff09\u7684\u591a\u6fc0\u9176\u6291\u5236\u5242\u3002\u8fd9\u6b3e\u72ec\u7279\u7684\u6ef4\u773c\u6db2\u6b63\u5728\u88ab\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u7ffc\u72b6\u80ec\u8089\uff0c\u5305\u62ec\u7f29\u5c0f\u75c5\u7076\u4f53\u79ef\u4ee5\u53ca\u7f13\u89e3\u5e38\u89c1\u7684\u56f0\u6270\u75c7\u72b6\u3002<\/span><\/p><p><span class=\"s1\">\u636e\u6211\u4eec\u6240\u77e5\uff0c\u76ee\u524d\u5168\u7403\u8303\u56f4\u5185\u5c1a\u65e0\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u7ffc\u72b6\u80ec\u8089\u7684\u836f\u7269\u7597\u6cd5\uff0c\u73b0\u6709\u7684\u6cbb\u7597\u9009\u62e9\u4ec5\u4e3a\u624b\u672f\u5207\u9664\u3002\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0cCBT-001 \u6709\u671b\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u7528\u4e8e\u6cbb\u7597\u7ffc\u72b6\u80ec\u8089\u53ca\u76f8\u5173\u56f0\u6270\u75c7\u72b6\u7684\u836f\u7269\u7597\u6cd5\uff0c\u5e76\u6709\u53ef\u80fd\u51cf\u5c11\u6216\u63a8\u8fdf\u5bf9\u624b\u672f\u5207\u9664\u7684\u9700\u6c42\u3002<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8248df6 elementor-widget elementor-widget-button\" data-id=\"8248df6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/cloudbreakpharma.com\/zh\/our-focus\/pterygium\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u7ffc\u72b6\u80ec\u8089<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5c4a50e\" data-id=\"5c4a50e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8aba8bd elementor-widget elementor-widget-video\" data-id=\"8aba8bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;hosted&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-hosted-video elementor-wrapper elementor-open-inline\">\n\t\t\t\t\t<video class=\"elementor-video\" src=\"https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/03\/cloudbreak_with_clinical_data-new-logo.mp4\" controls=\"\" preload=\"metadata\" controlslist=\"nodownload\"><\/video>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7a9d19a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7a9d19a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6063760\" data-id=\"6063760\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fea6195 elementor-widget elementor-widget-heading\" data-id=\"fea6195\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u6709\u836f\u7269\u6548\u6027\u80fd\u4e0e\u5b89\u5168\u6027<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0b1d3d elementor-widget elementor-widget-heading\" data-id=\"b0b1d3d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><p style=\"line-height: 107%;margin: 0pt 0in 8pt;direction: ltr\"><b><span style=\"color: var( --e-global-color-4862d202 );background-color: var( --e-global-color-3204c9d )\">2\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/span><sup style=\"color: var( --e-global-color-4862d202 );background-color: var( --e-global-color-3204c9d )\">7<\/sup><\/b><span style=\"color: var( --e-global-color-4862d202 );background-color: var( --e-global-color-3204c9d )\"><\/span><\/p><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-024262b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"024262b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c9ce449\" data-id=\"c9ce449\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c3b6e87 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"c3b6e87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"676\" height=\"380\" src=\"https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/04\/Phase-2_trial_graphic-1.png\" class=\"attachment-large size-large wp-image-799\" alt=\"\" srcset=\"https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/04\/Phase-2_trial_graphic-1.png 676w, https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/04\/Phase-2_trial_graphic-1-300x169.png 300w, https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/04\/Phase-2_trial_graphic-1-18x10.png 18w\" sizes=\"(max-width: 676px) 100vw, 676px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-cba7ddd\" data-id=\"cba7ddd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd6801e elementor-widget elementor-widget-text-editor\" data-id=\"fd6801e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>2\u671f\u4e34\u5e8a\u8bd5\u9a8c<u><a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT03049852\" target=\"_blank\" rel=\"noopener\">NCT03049852<\/a><\/u>\u5206\u4e3a\u4e24\u4e2a\u9636\u6bb5\u3002\u7b2c\u4e00\u9636\u6bb5\u5305\u62ec\u5bf924\u540d\u60a3\u8005\u8fdb\u884c CBT-001 \u5242\u91cf\u9012\u589e\uff0c\u4ee5\u786e\u5b9a\u6700\u5927\u8010\u53d7\u5242\u91cf\u3002\u7ed3\u679c\u8bc1\u660e\u4e86\u773c\u90e8\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u5168\u8eab\u836f\u7269\u66b4\u9732\u53ef\u5ffd\u7565\u4e0d\u8ba1\u3002\u5728\u7b2c2\u9636\u6bb5\uff0c51\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u4e3a\u671f4\u5468\u7684 TID \u5468\u671f CBT-001 (n=25) \u6216\u8f7d\u4f53 (n=23) \u7ed9\u836f\u6cbb\u7597\uff0c\u5e76\u968f\u8bbf\u81f3\u7b2c24\u5468\u3002\u5230\u7b2c4\u5468\uff0c\u7528\u836f\u7ec4\u7684\u5e73\u5747\u8840\u7ba1\u5206\u5e03\u8bc4\u5206\u6bd4\u5bf9\u7167\u7ec4\u663e\u8457\u4e0b\u964d, \u5e76\u4e00\u76f4\u6301\u7eed\u5230\u7b2c16\u5468\u3002\u6b64\u5916\uff0c\u5728\u7b2c4\u5468\u89c2\u5bdf\u5230\u75c5\u7076\u957f\u5ea6\u7684\u5e73\u5747\u53d8\u5316\u6bd4\u5bf9\u7167\u7ec4\u660e\u663e\u51cf\u5c11\uff0c\u5e76\u4e00\u76f4\u6301\u7eed\u5230\u7b2c8\u5468\u3002<sup>7<\/sup><\/p>\n<p>CBT-001 \u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0cCBT-001 \u7ec4\u4e2d\u5e38\u89c1\u62a5\u544a\u7684\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\u662f\u773c\u90e8\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e25\u91cd\u7a0b\u5ea6\u8f83\u8f7b\uff0c\u5e76\u5728\u6cbb\u7597\u540e\u5f97\u5230\u7f13\u89e3\u3002 \u6ca1\u6709\u60a3\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u800c\u505c\u6b62 CBT-001 \u6cbb\u7597\u3002<sup>7<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-9efc908 elementor-widget elementor-widget-heading\" data-id=\"9efc908\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><p style=\"line-height:150%\"><b>3\u671f\u4e34\u5e8a\u8bd5\u9a8c<sup>8<\/sup><\/b><span style=\"color: var( --e-global-color-4862d202 );background-color: var( --e-global-color-3204c9d )\"><\/span><\/p><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e804b91 elementor-widget elementor-widget-image\" data-id=\"e804b91\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"223\" src=\"https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/03\/Phase3_trial_graphic-002-1024x286.png\" class=\"attachment-large size-large wp-image-795\" alt=\"\" srcset=\"https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/03\/Phase3_trial_graphic-002-1024x286.png 1024w, https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/03\/Phase3_trial_graphic-002-300x84.png 300w, https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/03\/Phase3_trial_graphic-002-768x214.png 768w, https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/03\/Phase3_trial_graphic-002-1536x429.png 1536w, https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/03\/Phase3_trial_graphic-002-2048x572.png 2048w, https:\/\/cloudbreakpharma.com\/wp-content\/uploads\/2024\/03\/Phase3_trial_graphic-002-18x5.png 18w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7d5c81a elementor-widget elementor-widget-text-editor\" data-id=\"7d5c81a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>3\u671f\u4e34\u5e8a\u8bd5\u9a8c <span style=\"font-size: 12pt; font-family: Arial; color: black;\">(<\/span><u><span style=\"font-size: 12pt; font-family: Arial; color: #0563c1;\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05456425\" target=\"_blank\" rel=\"noopener\">NCT05456425<\/a><\/span><\/u><span style=\"font-size: 12pt; font-family: Arial; color: black;\">)<\/span> \u65e8\u5728\u8bc4\u4f30CBT-001\u5728\u7ffc\u72b6\u80ec\u8089\u60a3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<sup>8<\/sup><\/p><p><strong>\u65b9\u6848\u6807\u9898\uff1a<\/strong>\u5bf9\u7ffc\u72b6\u80ec\u8089\u60a3\u8005\u8fdb\u884c\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u968f\u673a\u3001\u8f7d\u4f53\u5bf9\u7167 12 \u4e2a\u6708\u5e73\u884c\u6bd4\u8f83 0.1% \u548c 0.2% CBT-001 \u4e0e\u8f7d\u4f53\uff08\u6bcf\u5929\u7ed9\u836f\u4e24\u6b21\uff09\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/p><p><strong>\u7814\u7a76\u76ee\u7684\uff1a<\/strong>\u8bc4\u4f30 0.1% \u548c 0.2% CBT-001 \u4e73\u5242\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f\uff0c\u6301\u7eed 24 \u4e2a\u6708\uff0c\u4e0e\u8f7d\u4f53\u76f8\u6bd4\uff0c\u5728\u51cf\u5c11\u7ffc\u72b6\u80ec\u8089\u773c\u7ed3\u819c\u5145\u8840\u548c\u9884\u9632\u7ffc\u72b6\u80ec\u8089\u8fdb\u5c55\u65b9\u9762\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/p><p><strong>\u76ee\u6807\u5165\u7ec4\uff1a<\/strong>600 \u540d\u60a3\u8005<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f8022e9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f8022e9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-03c4e5d\" data-id=\"03c4e5d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bf53709 elementor-widget elementor-widget-text-editor\" data-id=\"bf53709\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u4e3b\u8981\u7eb3\u5165\u6807\u51c6\uff1a<\/strong><\/p><ul style=\"margin-top: 0cm;\" type=\"disc\"><li><span lang=\"EN-US\">\u5e74\u9f84\u226512 \u5c81\u7684\u7537\u6027\u6216\u5973\u6027<\/span><\/li><li><span lang=\"EN-US\">\u89d2\u819c\u4e0a\u65b9\u7ffc\u72b6\u80ec\u8089\u75c5\u53d8\u957f\u5ea6\u22651.2\u6beb\u7c73 <\/span><\/li><li><span lang=\"EN-US\">\u22653\u7ea7\u7ed3\u819c\u5145\u8840<\/span><\/li><\/ul><div>\u00a0<\/div><div>\u00a0<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-cae5b39\" data-id=\"cae5b39\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a84969 elementor-widget elementor-widget-text-editor\" data-id=\"7a84969\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"MsoNormal\"><strong>\u4e3b\u8981\u6392\u9664\u6807\u51c6\uff1a<\/strong><\/p><ul style=\"margin-top: 0cm;\" type=\"disc\"><li class=\"MsoNormal\"><span lang=\"EN-US\">\u8fc7\u53bb 6 \u4e2a\u6708\u5185\u8fdb\u884c\u8fc7\u7ffc\u72b6\u80ec\u8089\u5207\u9664\u624b\u672f<\/span><\/li><li class=\"MsoNormal\"><span lang=\"EN-US\">\u9884\u671f\u5728\u7814\u7a76\u5165\u7ec4\u4e00\u5e74\u5185\u8fdb\u884c\u7ffc\u72b6\u80ec\u8089\u624b\u672f <\/span><\/li><li class=\"MsoNormal\"><span lang=\"EN-US\">\u9664\u7ffc\u72b6\u80ec\u8089\u4ee5\u5916\u7684\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u89d2\u819c\u5f02\u5e38<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ba653b elementor-widget elementor-widget-text-editor\" data-id=\"0ba653b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"x_MsoNormal\"><b data-olk-copy-source=\"MessageBody\">\u8be5III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\u60a3\u8005\u62db\u52df\uff0c\u9884\u8ba1\u5c06\u4e8e2026\u5e74\u7b2c\u4e09\u5b63\u5ea6\u516c\u5e03\u7814\u7a76\u7ed3\u679c\u3002\u00a0<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bdb28ec elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bdb28ec\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-78c2768\" data-id=\"78c2768\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eac31d8 elementor-widget elementor-widget-text-editor\" data-id=\"eac31d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"line-height: 107%; margin-top: 0pt; margin-bottom: 8pt; margin-left: 0in; direction: ltr; unicode-bidi: embed; word-break: normal;\"><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">BID, twice daily; DRC, data review committee; FGFR, fibroblast growth factor receptor; M, month; PDGFR, platelet-derived growth factor receptor; <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">PK, pharmacokinetics;<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">\u00a0<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">TID, three times daily; VEGFR, vascular endothelial growth factor receptor.<\/span><\/p><p style=\"line-height: 107%; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; direction: ltr; unicode-bidi: embed; word-break: normal;\"><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">1. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Shahraki<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\"> T, et al. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Ther Adv <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Ophthalmol<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">. 2021;13:25158414211020152. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">2. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Chu WK, et al. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Eye (Lond)<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">. 2020;34(6):1047-1050.<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\"> 3. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Wanzeler<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\"> ACV, et al. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Clin <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Ophthalmol<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">. 2018;12:833-837. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">4. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Palewski<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\"> M, et al. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Int J Environ Res Public Health. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">2022;19:11357. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">5. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Hilberg F, et al. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Cancer Res<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">. 2008;68:4774\u20134782. 6. Yang R, et al. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Invest <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Ophthalmol<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\"> Vis Sci <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">.2019;60(9):2087. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">7<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Whitcup<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\"> SM, et al. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">Ophthalmol<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; font-style: italic; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\"> Sci<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">. 2024. Publication in press. <\/span><u><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: #0563c1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-color: #0563C1; mso-style-textfill-fill-alpha: 100.0%;\"><a href=\"https:\/\/doi.org\/10.1016\/j.xops.2024.100502\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.xops.2024.100502<\/a><\/span><\/u><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">.<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Calibri; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\"> 8. <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">ClinicalTrials.gov. A clinical trial on safety and <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">efficacy <\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">of CBT-001 in patients with pterygium. Updated March 15, 2024. Accessed March 15, 2024. https:\/\/clinicaltrials.gov\/study\/NCT05456425.<\/span><span style=\"font-size: 9.0pt; font-family: Arial; mso-ascii-font-family: Arial; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: black; mso-color-index: 1; mso-font-kerning: 1.0pt; language: en-US; mso-style-textfill-type: solid; mso-style-textfill-fill-themecolor: text1; mso-style-textfill-fill-color: black; mso-style-textfill-fill-alpha: 100.0%;\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>CBT-001 A potential first-in-class treatment for patients with pterygium CBT-001 is currently in a Phase 3 clinical trial (NCT05456425) as a disease-modifying eyedrop therapy for pterygium. Breakthrough Innovation Our Core Product CBT-001 is a potential first-in-class drug therapy using a multi-kinase inhibitor targeting platelet-derived growth factor receptors (\u201cPDGFRs\u201d), fibroblast growth factor receptors (\u201cFGFRs\u201d), and vascular [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":0,"parent":48,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-771","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cloudbreakpharma.com\/zh\/wp-json\/wp\/v2\/pages\/771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cloudbreakpharma.com\/zh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cloudbreakpharma.com\/zh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cloudbreakpharma.com\/zh\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/cloudbreakpharma.com\/zh\/wp-json\/wp\/v2\/comments?post=771"}],"version-history":[{"count":0,"href":"https:\/\/cloudbreakpharma.com\/zh\/wp-json\/wp\/v2\/pages\/771\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/cloudbreakpharma.com\/zh\/wp-json\/wp\/v2\/pages\/48"}],"wp:attachment":[{"href":"https:\/\/cloudbreakpharma.com\/zh\/wp-json\/wp\/v2\/media?parent=771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}